Razonate DSR Capsules

Description

Razonate-DSR Capsules is a distinct and effective combination of Rabeprazole, a potent Proton Pump Inhibitor (PPI), and Domperidone, a well-established prokinetic and anti-emetic agent in sustained-release form.
This combination provides rapid, long-lasting suppression of gastric acid secretion along with improved gastrointestinal motility, making it highly effective in the management of GERD and other acid-peptic disorders.

Rabeprazole offers powerful acid control with minimal drug interaction potential, while Domperidone enhances gastric emptying and reduces reflux-associated symptoms such as nausea, bloating, and regurgitation.

 

Composition

Each hard gelatin capsule contains:

• Rabeprazole Sodium 20 mg (Enteric Coated)
• Domperidone 30 mg (Sustained Release)
• Excipients q.s.

Dosage & Administration

• Recommended dose: One capsule once daily, preferably before breakfast, or as directed by the physician.
• The capsule should be swallowed whole with water and not crushed or chewed.
• Duration of therapy depends on the severity of the condition and clinical response.

Indications

Razonate-DSR Capsules is indicated for the treatment of:

• Gastro-Esophageal Reflux Disease (GERD)
• Heartburn and acid regurgitation
• Acid Peptic Disorders
• Gastric and Duodenal Ulcers
• Dyspepsia
• Erosive Esophagitis
• Nausea and vomiting associated with acid reflux

Contra-Indications

Razonate-DSR Capsules is contraindicated in patients with:

• Known hypersensitivity to Rabeprazole, Domperidone, or any component of the formulation
• Gastrointestinal hemorrhage, mechanical obstruction, or perforation
• Prolactin-releasing pituitary tumors (prolactinoma)
• Moderate to severe hepatic impairment

Precautions & Warnings

• Use with caution in patients with liver dysfunction
• Long-term use of PPIs may increase the risk of vitamin B12 deficiency, hypomagnesemia, or osteoporosis-related fractures
• Domperidone should be used cautiously in patients with cardiac disorders or electrolyte imbalance
• Safety during pregnancy and lactation should be evaluated by a physician before use
• Not recommended for pediatric use unless prescribed by a healthcare professional

Drug Interactions

• Rabeprazole may alter absorption of drugs dependent on gastric pH
• Domperidone may interact with drugs that prolong QT interval
• Concomitant use with CYP3A4 inhibitors should be monitored

Storage

• Store in a cool, dry place
• Protect from light and moisture
• Keep out of reach of children
• Do not use after the expiry date printed on the pack

Disclaimer

To be sold by prescription of a registered medical practitioner only.